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NPR
The Coronavirus Crisis
Eloise LaCour, 3, gets her COVID-19 vaccination as part of Phase 1 clinical trials on use of the Pfizer-BioNTech vaccine in children 5 and younger.

COVID-19 Vaccine Trials Underway For Kids 5 And Younger

May 17, 2021
Parents who have enrolled their children in these studies say the risk is worth it for the greater good.
NPR
Shots - Health News
Leyda Valentine, a research coordinator, takes blood from Lisa Taylor as she participates in a COVID-19 vaccination study at Research Centers of America in Hollywood, Fla., in August 2020.

Long-Term Studies Of COVID-19 Vaccines Hurt By Placebo Recipients Getting Immunized

Feb 19, 2021
Researchers are trying to learn more about COVID-19 vaccines from original study participants. The quest is hampered because many people who first received a placebo shot are opting for the vaccine.
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NPR
Coronavirus Updates
Pharmaceutical company Merck says it is shelving its two COVID-19 vaccine candidates, saying that the results of clinical trials fell short of its goals.

Merck Stops Developing Both Of Its COVID-19 Vaccine Candidates

Jan 25, 2021
Merck, which previously made an Ebola vaccine, had been seen as a serious contender in the worldwide race to come up with an answer to the coronavirus.
NPR
Shots - Health News
Preliminary results of a study of the antiviral drug remdesivir show it is effective in shortening the recovery time for patients with COVID-19.

Antiviral Drug Remdesivir Shows Promise For Treating Coronavirus In NIH Study

Apr 29, 2020
The preliminary results showed that hospitalized patients who received remdesivir recovered 31% faster. Dr. Anthony Fauci hailed the findings as "quite good news."
NPR
Shots - Health News
A phlebotomist draws blood from a patient participating in a clinical trial for a cancer treatment. With hospitals focused on COVID-19, hundreds of studies are being put on hold.

Coronavirus Pandemic Brings Hundreds Of U.S. Clinical Trials To A Halt

Apr 11, 2020
COVID-19 has led to the suspension of many clinical studies of experimental treatments. About a quarter of the stopped trials involved new cancer treatments, an NPR analysis finds.
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NPR
Coronavirus Live Updates

Trump Tells The Story Of A 'Miracle' Cure For COVID-19. But Was It?

Apr 07, 2020
President Trump continues to promote hydroxychloroquine, a drug that has not been proved to work against coronavirus and COVID-19. He's relying on anecdotes, not science.
NPR
Coronavirus Live Updates
A scientist works in a lab at Moderna in Cambridge, Mass., in February. Moderna has developed an experimental coronavirus medicine, but an approved treatment could be more than a year away.

HHS To Help Companies Develop COVID-19 Vaccines

Mar 31, 2020
The Department of Health and Human Services outlined support for Moderna and Johnson & Johnson, as the companies work to develop coronavirus vaccines. Beefing up manufacturing capacity is a priority.
NPR
Coronavirus Live Updates
The Food and Drug Administration has authorized two malaria  — chloroquine and hydroxychloroquine — to be added to the national emergency stockpile for use in responding to COVID-19.

FDA OK's Addition To Stockpile Of Malaria Drugs For COVID-19

Mar 30, 2020
Chloroquine and hydroxycloroquine got the Food and Drug Administration's go-ahead to be put in the nation's strategic storehouses. But the drugs haven't been approved to treat coronavirus patients.
NPR
Shots - Health News
Gilead Sciences, headquartered in Foster City, Calif., makes remdesivir, one of the experimental drugs now being investigated as a possible treatment for COVID-19.

Might The Experimental Drug Remdesivir Work Against COVID-19?

Mar 21, 2020
It's too soon to know if the antiviral compound tested in 2014 as a potential Ebola treatment will hobble the coronavirus. Lab tests show promise, but studies in people with COVID-19 have only begun.
NPR
Goats and Soda

For HIV-Positive Babies, New Evidence Favors Starting Drug Treatment Just After Birth

Dec 04, 2019
Doctors used to worry that antiretroviral drugs were too powerful for HIV-positive newborns. More evidence is emerging that, in fact, early treatment can be safe and effective.
NPR
Shots - Health News
Already, Health Canada has posted safety and efficacy data online for four newly approved drugs; it plans to release <a href="https://clinical-information.canada.ca/content/clinical-information-release-in-progress">reports</a> for another 13 drugs and th

Canada's Decision To Make Public More Clinical Trial Data Puts Pressure On FDA

Oct 11, 2019
The U.S. Food and Drug Administration treats most data it gets on the development of new drugs and medical devices as confidential to companies. Critics say making the data public would help patients.
NPR
Shots - Health News
A study found that parachutes were no more effective than empty backpacks at protecting jumpers from aircraft. There was just one catch.

Researchers Show Parachutes Don't Work, But There's A Catch

Dec 22, 2018
A study found parachutes were no more effective than backpacks in preventing harm to people jumping from aircraft. The researchers' tongue-in-cheek experiment makes a deeper point about science.
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NPR
Shots - Health News
Getting people of different ethnicities and cultural backgrounds into clinical trials is not only a question of equity, doctors say. It's also a scientific imperative to make sure candidate drugs work and are safe in a broad cross-section of people.

Language Barrier Means Millions Of Elderly Can't Access Alzheimer's Trials

Oct 31, 2018
In the U.S., Alzheimer's clinical trials are largely limited to fluent English speakers, which leaves millions of patients without the opportunity to participate and scientists without diverse data.
NPR
Shots - Health News
Without including a "control group" of sepsis patients who get the usual mix of drugs and fluids, even a big study comparing two other experimental approaches won't deliver helpful answers, critics say.

Critics Trying To Stop A Big Study Of Sepsis Say The Research Puts Patients At Risk

Aug 27, 2018
The consumer advocacy group Public Citizen also says the multicenter study of life-threatening sepsis will at best produce confusing results. A Harvard doctor and designer of the research disagrees.
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NPR
Shots - Health News
Information that could refine the uses of approved drugs may lie deep inside patients' medical records.

To Improve Treatments, Researchers Want To Hunt For Clues In Medical Records

Jul 15, 2018
The vast amount of data held in electronic medical records and insurance bills contains bits that could be useful in refining the use of approved for drugs. But how to find it?
NPR
Shots - Health News
New treatments for migraines could change how physicians treat patients with the debilitating headaches.

Gone With A Shot? Hopeful New Signs Of Relief For Migraine Sufferers

Feb 03, 2018
Novel migraine therapies could change how physicians treat these debilitating headaches. But they are likely to be expensive and the long-term side effects will not be known for some time.
NPR
Shots - Health News
Speaker of the House Paul Ryan, center, and other lawmakers have a plan to overhaul the tax code that includes a provision that would repeal a tax credit for makers of drugs for rare diseases.

House Republicans Aim To Eliminate Tax Credits For Orphan Drugs

Nov 03, 2017
For more than three decades, pharmaceutical companies have claimed a 50 percent tax credit for the cost of clinical trials of drugs for rare diseases. The credit is now in jeopardy.
NPR
Shots - Health News

Scientists Are Not So Hot At Predicting Which Cancer Studies Will Succeed

Jul 04, 2017
A scientist tested his peers' ability to pick which cancer experiments would pan out. They failed more often than not, which doesn't say much for intuition or efficiency in the scientific process.
NPR
Shots - Health News
It turns out it's difficult to get people to adhere to the various dietary restrictions that come with participating in a fasting study.

Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It

May 01, 2017
Fasting every other day is no better for losing weight or keeping it off than restricting calories every day, a study suggests. And it's yet another example of how hard it is to study fasting.
NPR
Shots - Health News

Pricey New Cholesterol Drug's Effect On Heart Disease Is More Modest Than Hoped

Mar 17, 2017
The injectible drug Repatha is spectacularly good at lowering cholesterol. But the first big clinical trial of its ability to prevent heart attack and stroke finds smaller benefits.
NPR
Shots - Health News
Nancy Roach at a conference in 2016. She's long worked as a patient's advocate and recently teamed up with scientists to help improve the design of studies, as well as to improve clinical care.

Advice From Patients On A Study's Design Makes For Better Science

Feb 24, 2017
Increasingly, advocates for patients are in the room when big medical studies are designed. They demand answers to big questions: "Will the results of this study actually help anybody?"
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NPR
Shots - Health News
Anemic patients did not know about their condition during a testosterone trial.

Researchers Failed To Tell Testosterone Trial Patients They Were Anemic

Feb 21, 2017
Low levels of iron in the blood may indicate a serious but treatable medical condition if caught early, but patients in a testosterone trial were not informed, a bioethicist finds.
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NPR
Shots - Health News
Several new studies show mixed results for men taking testosterone supplements.

Does Testosterone Improve Older Men's Health? It Depends

Feb 21, 2017
Several studies out this week show mixed results for testosterone replacement. It appears to protect bone density and strength and prevent anemia, but there is no effect on memory and cognition.
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NPR
Shots - Health News
Research with living systems is never simple, scientists say, so there are many possible sources of variation in any experiment, ranging from the animals and cells to the details of lab technique.

What Does It Mean When Cancer Findings Can't Be Reproduced?

Jan 18, 2017
Results from some key cancer studies were different when the experiments were redone in different labs. Scientists don't yet know why but say the answer could have health implications for patients.
NPR
Shots - Health News
Karen Lorne, diagnosed with Lou Gehrig's disease in July, volunteers weekly with her certified therapy dog, Bailey, at the Ronald McDonald House in Chapel Hill, N.C.

Simplified Study Aims To Quickly Test A Long-Shot ALS Treatment

Oct 25, 2016
Fifty patients with Lou Gehrig's disease have volunteered for a study of a dietary supplement as an experimental treatment. Even a failure could help by eliminating a dead end from consideration.
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